A point estimator of the probability difference of overall treatment effect - simulation study

Pavla Krajíčková

Abstract


One of the aims of the meta-analysis of clinical trials is to determine the efficacy of a new type of
treatment. This efficacy is commonly measured by the difference between the efficacy of a standard
treatment and the new treatment. For binary data the difference can be measured by a probability
difference. We investigate, by simulations and using box plots, the basic statistical properties of the
point estimator of the probability difference of overall treatment effects in the meta-analysis based on
multicentre trials for various chosen situations. This estimator was suggested in Dokoupilova (2011).

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DOI: https://doi.org/10.2478/tatra.v50i3.134