Optimal Design for Population PK/PD Models
Abstract
We provide some details of the implementation of optimal design algorithm in the PkStaMp
library which is intended for constructing optimal sampling schemes for pharmacokinetic
(PK) and pharmacodynamic (PD) studies. We discuss different types of approximation of
individual Fisher information matrix and describe a user-defined option of the library.
library which is intended for constructing optimal sampling schemes for pharmacokinetic
(PK) and pharmacodynamic (PD) studies. We discuss different types of approximation of
individual Fisher information matrix and describe a user-defined option of the library.
Full Text:
PDFDOI: https://doi.org/10.2478/tatra.v51i1.161